Merseburg is a town in the south of the German state of Saxony-Anhalt on the river Saale, approx. 14 km south of Halle (Saale). It is the capital of the Saalekreis  district. It had a diocese founded by Archbishop Adalbert of Magdeburg. The University of Merseburg is located within the town
Merseburg was first mentioned in 850. King Henry the Fowler built a royal palace at Merseburg; in the 933 Battle of Riade, he gained his great victory over the Hungarians in the vicinity.

Thietmar of Merseburg became the first archbishop of the newly-created bishopric of Prague in Bohemia, appointed in 973. Prague had been part of the archbishopric of Mainz for a hundred years before that. From 968 until the Protestant Reformation, Merseburg was the seat of the bishop of Merseburg, and in addition to being for a time the residence of the margraves of Meissen, it was a favorite residence of the German kings during the 10th, 11th and 12th centuries. Fifteen diets were held here during the Middle Ages, when its fairs enjoyed the importance which was afterwards transferred to those of Leipzig. The town suffered severely during the Peasants' War and also during the Thirty Years' War.

From 1657 to 1738 Merseburg was the residence of the dukes of Saxe-Merseburg, after which it fell to the Electorate of Saxony. In 1815 following the Napoleonic Wars, the town became part of the Prussian Province of Saxony.

Merseburg is the site where the Merseburg Incantations were rediscovered in 1841. Written down in Old High German, they are hitherto the only preserved German documents with a heathen theme. One of them is a charm to release warriors caught during battle, and the other one is a charm to heal a horse's sprained foot.

At the beginning of the 20th century, Merseburg was transformed into an industrial site, which is largely due to the pioneering work done by people like Carl Bosch and Friedrich Bergius, who laid down the scientific fundamentals of the catalytic high-pressure ammonia synthesis from 1909 to 1913. Enterprises, too, blazed a trail in the course of the transformational process. Finally, a chemical park emerged which is one of the most modern sites of its kind in Europe with high ecological standards.

Merseburg was badly damaged in World War II. In 23 air raids 6200 dwellings were completely or partly destroyed.[2] The historic centre was nearly completely destroyed.

Briefly part of Saxony-Anhalt after the war, it was then administered within Bezirk Halle in East Germany. It became part of Saxony-Anhalt again during the reunification of Germany.