主题馆位于浦东世博园区B片区，占地面积约11.5公顷，总建筑面积达14.3万平方米，其中地上9.3万平方米，地下5万平方米，展览面积8万平方米，是世博会历史上规模最大的主题展馆。 上海世博会召开期间，主题馆的东侧一层展厅将作为“城市人馆”；北侧为生命阳光馆和公众参与馆；西侧展厅将分割为“生命馆”、“地球馆”；面积约7000平方米的中部多功能厅将作为入口大厅，连接各个展厅与功能区域。在2010年的世博园区里，主题馆充满了城市情怀和内在张力。带着上海里弄特征的“城市肌理”——均匀排列的坡顶、虚实相间的天井、错落有致的老虎窗，这些都被设计师提炼后运用在主题馆的屋面中；国内最大的双向大跨度无柱空间，也自豪地出现在主题馆内，25000平方米的超大展厅，可以让4架波音737飞机同时驶入.

Museum is located in the Pudong Expo Area B Area, an area of ​​about 11.5 hectares and a total construction area of ​​143,000 square meters, of which 93,000 square meters on the ground, underground 50,000 square meters exhibition area of ​​80,000 square meters, is the history of World Expo largest thematic pavilions. Shanghai World Expo will be held during the museum's exhibition hall will serve as the east side of a layer of "urban museum"; the north side of life and public participation in the sun Museum Museum; west side of the hall will be divided into "Life House", "Earth House"; central area of ​​about 7,000 square meters of multi-purpose hall will serve as the entrance hall, exhibition hall and connecting the various functional areas. In the 2010 World Expo site, a museum full of feelings and inner city tension. Shanghai neighborhood characteristics with the "urban fabric" - even ranked top of the hill, white patio actual situation, the patchwork of dormer windows, which are refined by the designer to use the roof of the museum; the largest two-way span column-free space, but also proud to appear in the theme of the museum, exhibition hall of 25,000 square meters large, allowing four Boeing 737 aircraft at the same time into the